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Example Input Mode:
Partner Data
CBIS
Matrix
Example Data Type:
Secondary Screen (Kd)
Primary Screen(% control or competition)
If the input file contains Primary and Secondary Data, use:
Primary
Secondary
Assay Data File:
.txt or .csv format - download examples:
Bromodomain
Kd
Primary
To highlight spots, select a compound(s), click 'fill' and select entries.
Create Images for:
Imatinib
Highlight These Spots (
fill
):
Imatinib|ABL1-nonphosphorylated|1.1
Imatinib|ABL2|10
Imatinib|BLK|520
Imatinib|CDK11|5500
Imatinib|CLK1|4500
Imatinib|CLK4|2100
Imatinib|CSF1R|11
Imatinib|DDR1|0.7
Imatinib|DDR2|15
Imatinib|DRAK1|5300
Imatinib|EPHA8|1400
Imatinib|FGR|2400
Imatinib|FRK|1500
Imatinib|FYN|3100
Imatinib|GAK|1000
Imatinib|HIPK4|960
Imatinib|IRAK1|1200
Imatinib|JNK1|5000
Imatinib|JNK3|3100
Imatinib|KIT|13
Imatinib|LCK|40
Imatinib|LYN|890
Imatinib|MELK|1900
Imatinib|PDGFRA|31
Imatinib|PDGFRB|14
Imatinib|PIP5K2C|380
Imatinib|PLK4|7800
Imatinib|RAF1|1700
Imatinib|TNNI3K|4300
Imatinib|TYK2(JH2domain-pseudokinase)|8700
Imatinib|ZAK|2600
Imatinib|ABL1-nonphosphorylated
Imatinib|ABL2
Imatinib|BLK
Imatinib|CDK11
Imatinib|CLK1
Imatinib|CLK4
Imatinib|CSF1R
Imatinib|DDR1
Imatinib|DDR2
Imatinib|DRAK1
Imatinib|EPHA8
Imatinib|FGR
Imatinib|FRK
Imatinib|FYN
Imatinib|GAK
Imatinib|HIPK4
Imatinib|IRAK1
Imatinib|JNK1
Imatinib|JNK3
Imatinib|KIT
Imatinib|LCK
Imatinib|LYN
Imatinib|MELK
Imatinib|PDGFRA
Imatinib|PDGFRB
Imatinib|PIP5K2C
Imatinib|PLK4
Imatinib|RAF1
Imatinib|TNNI3K
Imatinib|TYK2(JH2domain-pseudokinase)
Imatinib|ZAK
Imatinib|ABL1-nonphosphorylated|1.1
Imatinib|ABL2|10
Imatinib|BLK|520
Imatinib|CDK11|5500
Imatinib|CLK1|4500
Imatinib|CLK4|2100
Imatinib|CSF1R|11
Imatinib|DDR1|0.7
Imatinib|DDR2|15
Imatinib|DRAK1|5300
Imatinib|EPHA8|1400
Imatinib|FGR|2400
Imatinib|FRK|1500
Imatinib|FYN|3100
Imatinib|GAK|1000
Imatinib|HIPK4|960
Imatinib|IRAK1|1200
Imatinib|JNK1|5000
Imatinib|JNK3|3100
Imatinib|KIT|13
Imatinib|LCK|40
Imatinib|LYN|890
Imatinib|MELK|1900
Imatinib|PDGFRA|31
Imatinib|PDGFRB|14
Imatinib|PIP5K2C|380
Imatinib|PLK4|7800
Imatinib|RAF1|1700
Imatinib|TNNI3K|4300
Imatinib|TYK2(JH2domain-pseudokinase)|8700
Imatinib|ZAK|2600
clear
Select Highlight spots color from Pallette:
(also used in table view)
Tree Image Options
Restore default options
Spot options:
IndianRed
PaleGreen
Gold
PowderBlue
Fill?
Outline?
Outline thickness:
1
2
3
4
5
Select Spots Color from Pallette:
(spot highlight color below)
micro
nano
Spot Size:
Scaling Factor:
.1
.2
.3
.4
.5
.6
.7
.8
.9
1
1.1
1.2
1.3
Area increase factor:
100%
90%
80%
70%
60%
50%
(per change of 10x Kd or 10% Competition)
Legend options:
Left align Text
Right align Text
Label options:
Compound Name?
Compound Name Font:
.5
1
1.5
2
Show Assay Panel information?
Show Panel Spots?
Append Concentration? (i.e., 'AB500@1000nm'; check before loading.)
Background Image:
Target labels?
Dark Tree Branch image?
Hide Lipid, Mutant, ATypical and Pathogen?
Spot options:
Spot Color transparency level:
none
low
medium-low
medium
high
no color
Spot Cutoff Value:
Kd (nM) (Blank for no cutoff)
Spot outline only?
Format:
JPEG(200KB per image)
Publication Quality(5MB image)
Create Publication Quality (5MB bitmap) Image for:
Select Compound
Imatinib
size/quality
100
90
80
70
60
50
40
30
% of original
White Space Border:
Yes
No
Preview and Highlighting
Highlight an assay by clicking on the spot or checking the box next to the Gene Symbol Name.
Click 'Update' to create the new images.
Compound To Highlight:
None
Imatinib
Highlight Panel?
* WildType kinase assays appear in both the main TREEspot and Mutant kinase dendrogams.
Human Kinome image created by KINOMEscan.
2 images created. To download (copy and paste) all images to your local machine click Open/Browse Image Folder.
Images Saved To:
D:\Eurofins\PROD\Applications\FrontOffice_Discovery\StudyManagement\TreeSpot\HTSTools\TreeImages\512_1urmlccgoyf0pssqhah1qkfs\
Open/Browse Image Folder
View Options:
(These options do not modify the images that have been created, only the view on this page)
Imatinib
Legend
Show Selected
Size:
Select Size
small
medium
full size
Images per Row:
1
Legend Resize?
Hover the cursor to identify spots and click to highlighted it. To save an image click the Zoom/Download link.
Zoom/Download
Highlight
Locate an Assay
ABL1-nonphosphorylated
ABL1-nonphosphorylated
ABL2
BLK
CLK4
CSF1R
DDR1
DDR2
EPHA8
FGR
FRK
GAK
HIPK4
IRAK1
KIT
KIT
LCK
LYN
MELK
PDGFRA
PDGFRB
PIP5K2C
RAF1
ZAK
Legend
Data Table View:
Show All Data
Only Selected Compounds/Trees
TREE
spot
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